The function of the immune system declines with age. This is the
main cause for the increased susceptibility to infections and the
low effectiveness of vaccination in the elderly. To restore adequate
immune responses in older adults new approaches are indispensable.
Thus, I investigate the age related changes of the immune system
and further explore the effects of the rejuvenation of the hematopoietic
system on immune response. Thereby, my efforts concentrate on the
B- and T-cell compartment and on new approaches to improve vaccination
in the elderly.