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DNA damage response in HSCs upon aging
 

yH2AX- DNA damage response in HSCs upon aging


In this project we are working on identifying the role of DNA damage and the DNA damage response in hematopoietic stem cells (HSCs) and upon aging of these cells. We investigate mutation frequencies in the bone marrow and the response of long-term-HSCs to irradiation damage with respect to cell cycle checkpoints and apoptosis. With my work I want to help elucidating the mechanisms of aging of HSCs in terms of DNA damage.
  Geiger Laboratory
 
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