In this project we are working on identifying the role of DNA damage
and the DNA damage response in hematopoietic stem cells (HSCs) and
upon aging of these cells. We investigate mutation frequencies in
the bone marrow and the response of long-term-HSCs to irradiation
damage with respect to cell cycle checkpoints and apoptosis. With
my work I want to help elucidating the mechanisms of aging of HSCs
in terms of DNA damage.