Ageing of haematopoietic stem cells (HSCs) is associated with impaired
haematopoiesis in the elderly. Despite a large amount of data describing
the decline of HSC function upon ageing, the molecular mechanisms
of this process remain still largely unknown, which precludes rational
approaches to attenuate stem cell ageing.
Analysis of epigenetic differences in LT-HSCs upon aging: investigate
the role of acetylation on H4 and of methylation of DNA and of H3.