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Epigenetic changes of HSCs upon aging
 

Epigenetic changes of HSCs upon aging

Ageing of haematopoietic stem cells (HSCs) is associated with impaired haematopoiesis in the elderly. Despite a large amount of data describing the decline of HSC function upon ageing, the molecular mechanisms of this process remain still largely unknown, which precludes rational approaches to attenuate stem cell ageing.
Analysis of epigenetic differences in LT-HSCs upon aging: investigate the role of acetylation on H4 and of methylation of DNA and of H3.
  Geiger Laboratory
 
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