Ageing of haematopoietic stem cells (HSCs) is associated with impaired
haematopoiesis in the elderly. Despite a large amount of data describing
the decline of HSC function upon ageing, the molecular mechanisms
of this process remain still largely unknown, which precludes rational
approaches to attenuate stem cell ageing.
Cdc42 activity and CASIN treatment for the rejuvenation of hematopoietic
stem cells: the elevated activity of the small RhoGTPase Cdc42 in
aged hematopoietic stem cells (HSCs) is causally linked to HSC aging.
Pharmacological inhibition of Cdc42 activity functionally rejuvenates
aged stem cells by restoring cell polarity.