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HSCs aging – CDC42 and polarity
 

HSCs aging – CDC42 and polarity

Ageing of haematopoietic stem cells (HSCs) is associated with impaired haematopoiesis in the elderly. Despite a large amount of data describing the decline of HSC function upon ageing, the molecular mechanisms of this process remain still largely unknown, which precludes rational approaches to attenuate stem cell ageing.
Cdc42 activity and CASIN treatment for the rejuvenation of hematopoietic stem cells: the elevated activity of the small RhoGTPase Cdc42 in aged hematopoietic stem cells (HSCs) is causally linked to HSC aging. Pharmacological inhibition of Cdc42 activity functionally rejuvenates aged stem cells by restoring cell polarity.
  Geiger Laboratory
 
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