Hematopoietic stem cells (HSCs) are located within bone marrow (BM)
in a specific microenvironment referred to as the stem cell niche.
HSCs as well as more differentiated hematopoietic cells interact
in the BM with non-hematopoietic cells (CD45- cells) called stroma
cells. This interaction is central to hematopoiesis for regulating
cell proliferation, self-renewal, differentiation and location.
In this project we thus hypothesize that upon aging HSC niches also
undergo modifications, and that these aging-associated changes impair