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Influences of the aging niche on HSCs
 

Influences of the aging niche on HSCs

Hematopoietic stem cells (HSCs) are located within bone marrow (BM) in a specific microenvironment referred to as the stem cell niche. HSCs as well as more differentiated hematopoietic cells interact in the BM with non-hematopoietic cells (CD45- cells) called stroma cells. This interaction is central to hematopoiesis for regulating cell proliferation, self-renewal, differentiation and location.  In this project we thus hypothesize that upon aging HSC niches also undergo modifications, and that these aging-associated changes impair HSCs functions.
  Geiger Laboratory
 
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