Aging limits the life span of an organism mainly due to decrease
in regenerative capacity of several organ systems. Most of the organ
systems are stem cell based and stem function and maintenance go
down during aging, limiting the regenerative potential of an organ.
I am very much interested in canonical/non-canonical wnt signaling
mechanisms and involvement of small RhoGTPase Cdc42 regulating stem
cell maintenance, function and quiescence during aging.