Ageing of haematopoietic stem cells (HSCs) is associated with impaired
haematopoiesis in the elderly. Despite a large amount of data describing
the decline of HSC function upon ageing, the molecular mechanisms
of this process remain still largely unknown, which precludes rational
approaches to attenuate stem cell ageing.
The shift from canonical to non canonical Wnt5a signaling: upon
aging the hematopoietic system shifts from a mainly canonical to
a mainly non canonical Wnt pathway (decrease in β-catenin and Axin-2
levels); changes in Notch signaling pathway are also involved (cross-talk
between Wnt and Notch pathway).