Welcome to the geigerlab
Our Lab is interested in stem cells, especially hematopoietic and intestinal stem cells and aging of stem cells. We work on unraveling intrinsic changes in stem cells upon aging as well as how the niche is affecting stem cell behaviour. Furthermore, we investigate the involvement of hematopoietic stem cells (HSCs) in an aging immune system and the causes and consequences of HSC transformation. Another main topic of our research is how clonality and heterogeneity are achieved in stem cells.
News from the Lab
ERC Starting Grant for Junior-Professor Ani Grigoryan
1.5 million euros for research into ageing blood stem cells
Blood is produced from blood stem cells in the bone marrow. When this haematopoietic system ages, people over 65 often suffer from anaemia, impaired immune responses or even leukaemia.In the "MANAGE HSC" study, junior professor Ani Grigoryan from the Institute of Molecular Medicine wants to investigate how the bone marrow changes with age and how this affects the ageing of human blood stem cells. The junior research group leader has been awarded a Starting Grant from the European Research Council worth one and a half million euros.
Geigerlab in the newspaper
Congratulations Dr. Ali Hageb!
Ali successfully defended his PhD thesis!
Congratulations!
Congratulations Dr. Amanda Amoah !
Amanda successfully defended her PhD Thesis!
Congratulations!
Congratulations Dr. Mona Vogel !
Mona defended her PhD thesis "summa cum laude" and at the same day received a ProTrainU grant from Ulm University.
Double Congratulations !
Ulm University awarded five young researchers start-up funding and presented their scientific work. Dr. Hanna Leins is investigating the relationship between the microbiome and the immune system.
At the annual meeting of the German society for aging research our Post-Doc Mehmet received the Fritz Boege Prize for Innovation for his poster: "Hematopoietic stem cells in perisinusoidal niches are protected from aging".
pH regulates hematopoietic stem cell potential via polyamines
Kumar S, Vassallo JD, Nattamai KJ, Hassan A, Karns R, Vollmer A, Soller K, Sakk V, Sacma M, Nemkov T, D'Alessandro A, Geiger H.
EMBO Rep. 2023 May
Mehmet Saçma, Francesca Matteini, Medhanie A. Mulaw, Ali Hageb, Ruzhica Bogeska, Vadim Sakk, Angelika Vollmer, Gina Marka, Karin Soller, Michael D. Milsom, Maria Carolina Florian and Hartmut Geiger
STAR Protocols. 2022 Jun
A Limited Role for AMD3100 Induced Stem Cell Mobilization for Modulation of Thoracic Trauma Outcome
Vogel M, Möhrle B, Sakk V, Brown A, Palmer A, Braumüller S, Huber-Lang M, Allgöwer A, Cancelas JA, Geiger H.
Shock. 2022 Jun
Reduced adhesion of aged intestinal stem cells contributes to an accelerated clonal drift
Hageb A, Thalheim T, Nattamai KJ, Möhrle B, Saçma M, Sakk V, Thielecke L, Cornils K, Grandy C, Port F, Gottschalk KE, Mallm JP, Glauche I, Galle J, Mulaw MA, Geiger H.
Life Sci Alliance. 2022 Apr
Nalapareddy K, Hassan A, Sampson LL, Zheng Y, Geiger H.
iScience. 2021 Mar
Aging of human hematopoietic stem cells is linked to changes in Cdc42 activity.
Amoah A, Keller A, Emini R, Hoenicka M, Liebold A, Vollmer A, Eiwen K, Soller K, Sakk V, Zheng Y, Florian MC, Geiger H.
Haematologica. 2021 Jan 14
Florian MC, Leins H, Gobs M, Han Y, Marka G, Soller K, Vollmer A, Sakk V, Nattamai KJ, Rayes A, Zhao X, Setchell K, Mulaw M, Wagner W, Zheng Y, Geiger H.
Aging Cell. 2020 Aug