Welcome to the geigerlab
Our Lab is interested in stem cells, especially hematopoietic and intestinal stem cells and aging of stem cells. We work on unraveling intrinsic changes in stem cells upon aging as well as how the niche is affecting stem cell behaviour. Furthermore, we investigate the involvement of hematopoietic stem cells (HSCs) in an aging immune system and the causes and consequences of HSC transformation. Another main topic of our research is how clonality and heterogeneity are achieved in stem cells.
News from the Lab
Geigerlab in the newspaper
Congratulations Dr. Amanda Amoah !
Amanda successfully defended her PhD Thesis!
Congratulations Dr. Mona Vogel !
Mona defended her PhD thesis "summa cum laude" and at the same day received a ProTrainU grant from Ulm University.
Double Congratulations !
Fast and high-fidelity in situ 3D imaging protocol for stem cells and niche components for mouse organs and tissues
Mehmet Saçma, Francesca Matteini, Medhanie A. Mulaw, Ali Hageb, Ruzhica Bogeska, Vadim Sakk, Angelika Vollmer, Gina Marka, Karin Soller, Michael D. Milsom, Maria Carolina Florian and Hartmut Geiger
STAR Protocols. 2022 Jun
A Limited Role for AMD3100 Induced Stem Cell Mobilization for Modulation of Thoracic Trauma Outcome
Vogel M, Möhrle B, Sakk V, Brown A, Palmer A, Braumüller S, Huber-Lang M, Allgöwer A, Cancelas JA, Geiger H.
Shock. 2022 Jun
Reduced adhesion of aged intestinal stem cells contributes to an accelerated clonal drift
Hageb A, Thalheim T, Nattamai KJ, Möhrle B, Saçma M, Sakk V, Thielecke L, Cornils K, Grandy C, Port F, Gottschalk KE, Mallm JP, Glauche I, Galle J, Mulaw MA, Geiger H.
Life Sci Alliance. 2022 Apr
Suppression of elevated Cdc42 activity promotes the regenerative potential of aged intestinal stem cells.
Nalapareddy K, Hassan A, Sampson LL, Zheng Y, Geiger H.
iScience. 2021 Mar
Aging of human hematopoietic stem cells is linked to changes in Cdc42 activity.
Amoah A, Keller A, Emini R, Hoenicka M, Liebold A, Vollmer A, Eiwen K, Soller K, Sakk V, Zheng Y, Florian MC, Geiger H.
Haematologica. 2021 Jan 14
Inhibition of Cdc42 activity extends lifespan and decreases circulating inflammatory cytokines in aged female C57BL/6 mice.
Florian MC, Leins H, Gobs M, Han Y, Marka G, Soller K, Vollmer A, Sakk V, Nattamai KJ, Rayes A, Zhao X, Setchell K, Mulaw M, Wagner W, Zheng Y, Geiger H.
Aging Cell. 2020 Aug