2022

Fast and high-fidelity in situ 3D imaging protocol for stem cells and niche components for mouse organs and tissues

Mehmet Saçma, Francesca Matteini, Medhanie A. Mulaw, Ali Hageb, Ruzhica Bogeska, Vadim Sakk, Angelika Vollmer, Gina Marka, Karin Soller, Michael D. Milsom, Maria Carolina Florian and Hartmut Geiger

Star Protocols. 2022 Jun

A Limited Role for AMD3100 Induced Stem Cell Mobilization for Modulation of Thoracic Trauma Outcome

Vogel M, Möhrle B, Sakk V, Brown A, Palmer A, Braumüller S, Huber-Lang M, Allgöwer A, Cancelas JA, Geiger H.

Shock. 2022 Jun

Reduced adhesion of aged intestinal stem cells contributes to an accelerated clonal drift

Hageb A, Thalheim T, Nattamai KJ, Möhrle B, Saçma M, Sakk V, Thielecke L, Cornils K, Grandy C, Port F, Gottschalk KE, Mallm JP, Glauche I, Galle J, Mulaw MA, Geiger H

Life Sci Alliance. 2022 Apr

Aging of intestinal stem cells

Nalapareddy K, Zheng Y, Geiger H

Stem Cell Reports. 2022 Apr

Autophagy in mesenchymal progenitors protects mice against bone marrow failure after severe intermittent stress

Landspersky T, Saçma M, et al., Geiger H, Schreck C, Oostendorp RAJ

Blood. 2022 Feb

Aging of human hematopoietic stem cells is linked to changes in Cdc42 activity

Amoah A, Keller A, Emini R, Hoenicka M, Liebold A, Vollmer A, Eiwen K, Soller K, Sakk V, Zheng Y, Florian MC, Geiger H

Haematologica. 2022 Feb

2021

Septins in Stem Cells

Schuster T, Geiger H

Front Cell Dev Biol. 2021 Dec

Cdc42-Borg4-Septin7 axis regulates HSC polarity and function

Kandi R, Senger K, Grigoryan A, Soller K, Sakk V, Schuster T, Eiwen K, Menon MB, Gaestel M, Zheng Y, Florian MC, Geiger H

EMBO Rep. 2021 Dec

Autophagy In Mesenchymal Progenitors Protects Mice Against Bone Marrow Failure After Severe Intermittent Stress

Landspersky T, Saçma M, Rivière J, et al., Geiger H, Schreck C, Oostendorp RAJ

Blood. 2021 Oct

Reconstructing Boolean network ensembles from single-cell data for unraveling dynamics in the aging of human hematopoietic stem cells

Schwab JD, Ikonomi N, Werle SD, Weidner FM, Geiger H, Kestler HA.

Comput Struct Biotechnol J. 2021 Sep

Persistent JunB activation in fibroblasts disrupts stem cell niche interactions enforcing skin aging

Maity P, Singh K, Krug L, Koroma A, Hainzl A, Bloch W, Kochanek S, Wlaschek M, Schorpp-Kistner M, Angel P, Ignatius A, Geiger H, Scharffetter-Kochanek K.

Cell Rep. 2021 Aug

An aged bone marrow niche restrains rejuvenated hematopoietic stem cells

Guidi N, Marka G, Sakk V, Zheng Y, Florian MC, Geiger H.

Stem Cells. 2021 Apr

Attrition of X Chromosome Inactivation in Aged Hematopoietic Stem Cells

Grigoryan A, Pospiech J, Krämer S, Lipka D, Liehr T, Geiger H, Kimura H, Mulaw MA, Florian MC.

Stem Cell Reports. 2021 Apr

Suppression of elevated Cdc42 activity promotes the regenerative potential of aged intestinal stem cells.

Nalapareddy K, Hassan A, Sampson LL, Zheng Y, Geiger H.

iScience. 2021 Mar

A Wnt5a-Cdc42 axis controls aging and rejuvenation of hair-follicle stem cells

Tiwari RL, Mishra P, Martin N, George NO, Sakk V, Soller K, Nalapareddy K, Nattamai K, Scharffetter-Kochanek K, Florian MC, Geiger H.

Aging (Albany NY). 2021 Feb

Aging of human hematopoietic stem cells is linked to changes in Cdc42 activity

Amoah A, Keller A, Emini R, Hoenicka M, Liebold A, Vollmer A, Eiwen K, Soller K, Sakk V, Zheng Y, Florian MC, Geiger H.

Haematologica. 2021 Jan

2020

Repolarization of HSC attenuates HSCs failure in Shwachman-Diamond syndrome.

Kumar S, Nattamai KJ, Hassan A, Amoah A, Karns R, Zhang C, Liang Y, Shimamura A, Florian MC, Bissels U, Luevano M, Bosio A, Davies SM, Mulaw M, Geiger H, Myers KC.

Leukemia. 2020 Oct

Inhibition of Cdc42 activity extends lifespan and decreases circulating inflammatory cytokines in aged female C57BL/6 mice

Florian MC, Leins H, Gobs M, Han Y, Marka G, Soller K, Vollmer A, Sakk V, Nattamai KJ, Rayes A, Zhao X, Setchell K, Mulaw M, Wagner W, Zheng Y, Geiger H.

Aging Cell. 2020 Aug

TLR4-dependent shaping of the wound site by MSCs accelerates wound healing

Munir S, Basu A, Maity P, Krug L, Haas P, Jiang D, Strauss G, Wlaschek M, Geiger H, Singh K, Scharffetter-Kochanek K.

EMBO Rep. 2020 Mar

Immunological history governs human stem cell memory CD4 heterogeneity via the Wnt signaling pathway

Kared H, Tan SW, Lau MC, Chevrier M, Tan C, How W, Wong G, Strickland M, Malleret B, Amoah A, Pilipow K, Zanon V, Govern NM, Lum J, Chen JM, Lee B, Florian MC, Geiger H, Ginhoux F, et al., Larbi A

Nat Commun. 2020 Feb

2019

HPRT and Purine Salvaging Are Critical for Hematopoietic Stem Cell Function

Vogel M, Moehrle B, Brown A, Eiwen K, Sakk V, Geiger H

Stem Cells. 2019 Dec

Haematopoietic stem cells in perisinusoidal niches are protected from ageing

Saçma M, Pospiech J, Bogeska R, de Back W, Mallm JP, Sakk V, Soller K, Marka G, Vollmer A, Karns R, Cabezas-Wallscheid N, Trumpp A, Méndez-Ferrer S, Milsom MD, Mulaw MA, Geiger H, Florian MC.

Nat Cell Biol. 2019 Nov

Lazy Sundays: role of day of the week and reactivity on objectively measured physical activity in older people

Klenk J, Peter RS, Rapp K, Dallmeier D, Rothenbacher D, Denkinger M, Büchele G; ActiFE Study Group, Becker T, Böhm B, Scharffetter-Kochanek K, Stingl J, Koenig W, Riepe M, Peter R, Geiger H, Ludolph A, von Arnim C, et al., Laszlo R

Eur Rev Aging Phys Act. 2019 Oct

Functional and clinical characterization of the alternatively spliced isoform AML1-ETO9a in adult patients with translocation t(8;21)(q22;q22.1) acute myeloid leukemia (AML)

Agrawal M, Schwarz P, Giaimo BD, Bedzhov I, Corbacioglu A, Weber D, Gaidzik VI, Jahn N, Rücker FG, Schroeder T, Kindler T, Wattad M, Götze K, Lübbert M, et al., Bullinger L, Paschka P, Döhner K, Oswald F

Leukemia. 2019 Aug

Hematopoietic Stem Cell Dynamics Are Regulated by Progenitor Demand: Lessons from a Quantitative Modeling Approach

Klose M, Florian MC, Gerbaulet A, Geiger H, Glauche I

Stem Cells. 2019 Jul

Latexin regulation by HMGB2 is required for hematopoietic stem cell maintenance

Zhang C, Fondufe-Mittendorf YN, Wang C, Chen J, Cheng Q, Zhou D, Zheng Y, Geiger H, Liang Y

Haematologica. 2019 Jun

The lifespan quantitative trait locus gene Securin controls hematopoietic progenitor cell function

Brown A, Schuetz D, Han Y, Daria D, Nattamai KJ, Eiwen K, Sakk V, Pospiech J, Saller T, van Zant G, Wagner W, Geiger H

Haematologica. 2019 May

Distinct Dynamics of Stem and Progenitor Cells in Blood of Polytraumatized Patients

Vogel M, Christow H, Manz I, Denkinger M, Amoah A, Schütz D, Brown A, Möhrle B, Schaffer A, Kalbitz M, Gebhard F, Mayer B, Huber-Lang M, Geiger H

Shock. 2019 Apr

2018

Impaired immune surveillance accelerates accumulation of senescent cells and aging

Ovadya Y, Landsberger T, Leins H, Vadai E, Gal H, Biran A, Yosef R, Sagiv A, Agrawal A, Shapira A, Windheim J, Tsoory M, Schirmbeck R, Amit I, Geiger H, Krizhanovsky V.

Nat Commun. 2018 Dec

LaminA/C regulates epigenetic and chromatin architecture changes upon aging of hematopoietic stem cells

Grigoryan A, Guidi N, Senger K, Liehr T, Soller K, Marka G, Vollmer A, Markaki Y, Leonhardt H, Buske C, Lipka DB, Plass C, Zheng Y, Mulaw MA, Geiger H, Florian MC

Genome Biol. 2018 Nov

Chromosome integrity checkpoints in stem and progenitor cells: transitions upon differentiation, pathogenesis, and aging

Brown A, Geiger H

Cell Mol Life Sci. 2018 Oct

Aging alters the epigenetic asymmetry of HSC division

Florian MC, Klose M, Sacma M, Jablanovic J, Knudson L, Nattamai KJ, Marka G, Vollmer A, Soller K, Sakk V, Cabezas-Wallscheid N, Zheng Y, Mulaw MA, Glauche I, Geiger H

PLoS Biol. 2018 Sep

A non-myeloablative conditioning approach for long-term engraftment of human and mouse hematopoietic stem cells

Du W, Liu W, Mizukawa B, Shang X, Sipple J, Wunderlich M, Geiger H, Davies S, Mulloy J, Pang Q, Zheng Y

Leukemia. 2018 Sep

Epigenetic age-predictor for mice based on three CpG sites

Han Y, Eipel M, Franzen J, Sakk V, Dethmers-Ausema B, Yndriago L, Izeta A, de Haan G, Geiger H, Wagner W

Elife. 2018 Aug

Aged murine hematopoietic stem cells drive aging-associated immune remodeling

Leins H, Mulaw M, Eiwen K, Sakk V, Liang Y, Denkinger M, Geiger H, Schirmbeck R

Blood. 2018 Aug

Special section: Replication stress, a threat to the nuclear and mitochondrial genome

Wiesmüller L, Scharffetter-Kochanek K, Geiger H

Mutat Res. 2018 Jan

Rho-inhibiting C2IN-C3 fusion toxin inhibits chemotactic recruitment of human monocytes ex vivo and in mice in vivo

Martin T, Möglich A, Felix I, Förtsch C, Rittlinger A, Palmer A, Denk S, Schneider J, Notbohm L, Vogel M, Geiger H, Paschke S, Huber-Lang M, Barth H.

Arch Toxicol. 2018 Jan

2017

Balance your folate or the yin and yang of folate in hematopoiesis

Geiger H

Haematologica. 2017 Dec

RHOA GTPase Controls YAP-Mediated EREG Signaling in Small Intestinal Stem Cell Maintenance

Liu M, Zhang Z, Sampson L, Zhou X, Nalapareddy K, Feng Y, Akunuru S, Melendez J, Davis AK, Bi F, Geiger H, Xin M, Zheng Y

Stem Cell Reports. 2017 Dec

Loss of DEK induces radioresistance of murine restricted hematopoietic progenitors

Serrano-Lopez J, Nattamai K, Pease NA, Shephard MS, Wellendorf AM, Sertorio M, Smith EA, Geiger H, Wells SI, Cancelas JA, Privette Vinnedge LM.

Exp Hematol. 2017 Dec

The Spindle Assembly Checkpoint Is Required for Hematopoietic Progenitor Cell Engraftment

Brown A, Pospiech J, Eiwen K, Baker DJ, Moehrle B, Sakk V, Nattamai K, Vogel M, Grigoryan A, Geiger H

Stem Cell Rep. 2017 Nov

Heterodimerization of AML1/ETO with CBFβ is required for leukemogenesis but not for myeloproliferation

Thiel VN, Giaimo BD, Schwarz P, Soller K, Vas V, Bartkuhn M, Blätte TJ, Döhner K, Bullinger L, Borggrefe T, Geiger H, Oswald F

Leukemia. 2017 Nov

HSC Niche Biology and HSC Expansion Ex Vivo

Kumar S, Geiger H

Trends Mol Med. 2017 Sep