Clonality

Hematopoiesis is regarded as a polyclonal event with the understanding that most HSCs are equipotent and multiple clones
support blood production throughout the life. Stem cell clonality and heterogenous contribution of stem cell clones during
development and aging is a topic of immense interest in stem cell field. We are interested in studying the HSC clonality under
different conditions like age, niche factors, disease state and genetic mouse models.